PDE4D inhibition ameliorates cardiac hypertrophy and heart

pede4dPhosphodiesterase 4D (PDE4D) expression is upregulated in angiotensin (Ang) II-induced hypertensive mice. We first established a hypertensive model in wild-type (WT,The PDE4 family contains four genes (PDE4A to PDE4D), only PDE4A, PDE4B, and PDE4D are expressed in the heart, each of which regulates different cAMP-dependent